Ugarte, Fernando Sousae, Rebekah Cinquin, Bertrand Martin, Eric W Krietsch, Jana Sanchez, Gabriela Inman, Margaux Tsang, Herman Warr, Matthew Passegué, Emmanuelle
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Published in
Stem cell reports
Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem...
Harburg, Gwyndolen Compton, Jennifer Liu, Wei Iwai, Naomi Zada, Shahrzad Marlow, Rebecca Strickland, Phyllis Zeng, Yi Arial Hinck, Lindsay
Published in
Stem cell reports
WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negatively regulate WNT signaling. The absence of SLIT/...
