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Genome-wide analysis of alternative pre-mRNA splicing and RNA-binding specificities of the Drosophila hnRNP A/B family m... PDF available through Get Fulltext Research

Blanchette, Marco Green, Richard E MacArthur, Stewart Brooks, Angela N Brenner, Steven E Eisen, Michael B Rio, Donald C

Published in Molecular cell

Heterogeneous nuclear ribonucleoproteins (hnRNPs) have been traditionally seen as proteins packaging RNA nonspecifically into ribonucleoprotein particles (RNPs), but evidence suggests specific cellular functions on discrete target pre-mRNAs. Here we report genome-wide analysis of alternative splicing patterns regulated by four Drosophila homologs o...

The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1. PDF available through Get Fulltext Research

Michlewski, Gracjan Sanford, Jeremy R Cáceres, Javier F

Published in Molecular cell

The SR protein SF2/ASF has been initially characterized as a splicing factor but has also been shown to mediate postsplicing activities such as mRNA export and translation. Here we demonstrate that SF2/ASF promotes translation initiation of bound mRNAs and that this activity requires the presence of the cytoplasmic cap-binding protein eIF4E. SF2/AS...

Cancer/Testis Antigen PASD1 Silences the Circadian Clock. PDF available through Get Fulltext Research

Michael, Alicia K Harvey, Stacy L Sammons, Patrick J Anderson, Amanda P Kopalle, Hema M Banham, Alison H Partch, Carrie L

Published in Molecular cell

The circadian clock orchestrates global changes in transcriptional regulation on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1. Pathways driven by other bHLH-PAS transcription factors have a homologous repressor that modulates activity on a tissue-specific basis, but none have been identified for CLOCK:BMAL1. We show here that the...

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