Pietras, Eric M Reynaud, Damien Kang, Yoon-A Carlin, Daniel Calero-Nieto, Fernando J Leavitt, Andrew D Stuart, Joshua M Göttgens, Berthold Passegué, Emmanuelle
Published in
Cell stem cell
Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production. We find that all ...
Smith-Berdan, Stephanie Nguyen, Andrew Hassanein, Deena Zimmer, Matthew Ugarte, Fernando Ciriza, Jesús Li, Dean García-Ojeda, Marcos E Hinck, Lindsay Forsberg, E Camilla
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Published in
Cell stem cell
Specific bone marrow (BM) niches are critical for hematopoietic stem cell (HSC) function during both normal hematopoiesis and in stem cell transplantation therapy. We demonstrate that the guidance molecule Robo4 functions to specifically anchor HSCs to BM niches. Robo4-deficient HSCs displayed poor localization to BM niches and drastically reduced ...
