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JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without... PDF available through Get Fulltext Research

Santaguida, Marianne Schepers, Koen King, Bryan Sabnis, Amit J Forsberg, E Camilla Attema, Joanne L Braun, Benjamin S Passegué, Emmanuelle

Published in Cancer cell

Loss of the JunB/AP-1 transcription factor induces a myeloproliferative disease (MPD) arising from the hematopoietic stem cell (HSC) compartment. Here, we show that junB inactivation deregulates the cell-cycle machinery and increases the proliferation of long-term repopulating HSCs (LT-HSCs) without impairing their self-renewal or regenerative pote...

The somatic genomic landscape of chromophobe renal cell carcinoma. PDF available through Get Fulltext Research

Davis, Caleb F Ricketts, Christopher J Wang, Min Yang, Lixing Cherniack, Andrew D Shen, Hui Buhay, Christian Kang, Hyojin Kim, Sang Cheol Fahey, Catherine C ...

Published in Cancer cell

We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origi...

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. PDF available through Get Fulltext Research

Lee, John K Phillips, John W Smith, Bryan A Park, Jung Wook Stoyanova, Tanya McCaffrey, Erin F Baertsch, Robert Sokolov, Artem Meyerowitz, Justin G Mathis, Colleen ...

Published in Cancer cell

MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to transform human prostate epithelial cells to prostat...

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