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Genomic locus on chromosome 1 regulates susceptibility to spontaneous arthritis in mice deficiency of IL-1RA PDF available through Get Fulltext Research

Deng, Nan Jiao, Yan Cao, Yanhong Liu, Xiaoyun Ma, Yonghui Hasty, Karen A Brand, David D Stuart, John M Gu, Weikuan

Published in BMC Immunology

BackgroundTo understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1āˆ’/āˆ’ mice that are resistant to spontaneous arthritis into BALB/cāˆ’/āˆ’ mice which are susceptible....

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