Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis.
Published in Arthritis & Rheumatism
Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheuma...
Published in Arthritis & Rheumatism
Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fl...
Effect of cyclophosphamide, hydrocortisone and levamisole on collagen-induced arthritis in rats.
Published in Arthritis & Rheumatism
The immune response of rats to type II collagen was modified by pretreating the rats with levamisole, hydrocortisone, or cyclophosphamide. Rats were observed for the development of collagen-induced arthritis and were bled serially for the determination of antibody levels to type II collagen. Levamisole had a slight but not significant potentiating ...
Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice.
Published in Arthritis & Rheumatism
Proceedings: Evidence of cell-mediated immunity to collagen in patients with progressive systemic sclerosis.
Published in Arthritis & Rheumatism
Collagen-induced arthritis in rats. Comparison of vitreous and cartilage-derived collagens.
Published in Arthritis & Rheumatism
An oil emulsion of purified type II collagen from bovine articular cartilage when injected intradermally into rats induced an inflammatory polyarthritis in 4 of 12 animals. When similarly injected, collagen purified from bonve vitreous induced arthritis in 6 of 12 animals. Studies of humoral and cell-mediated immunity to both collagen preparations ...
Arthritis in mice that are deficient in interleukin-1 receptor antagonist is dependent on genetic background.
Published in Arthritis & Rheumatism
Serum transfer of collagen-induced arthritis. II. Identification and localization of autoantibody to type II collagen in...
Published in Arthritis & Rheumatism
Collagen-induced arthritis can be transferred from immunized arthritic rats to unimmunized recipients by intravenous injection of an immunoglobulin concentrate of sera. This study identifies antibodies in the transfer concentrate which localize to the articular surface of cartilage in joints of recipients. Immunoglobulin can also be demonstrated in...
Type II collagen-induced arthritis in mice. II. Passive transfer and suppression by intravenous injection of anti-type I...
Published in Arthritis & Rheumatism
The passive transfer of high levels of anti-type II collagen antibody from mice with type II collagen-induced arthritis may transfer arthritis to syngeneic recipient animals. However, the transfer of either arthritogenic or sub-arthritogenic doses of polyclonal anti-type II collagen antibody, or non-arthritogenic monoclonal anti-type II collagen an...
Collagen-induced arthritis in rats. Evaluation of early immunologic events.
Published in Arthritis & Rheumatism
When rats were injected intradermally with an oil emulsion of native type II collagen, they developed an inflammatory polyarthritis. The incidence and severity of arthritis increased as the amount of collagen injected was increased. Rats 4 1/2 weeks old were the most susceptible to the development of arthritis, whereas weanling and older animals we...
