Guo, Yirui Partch, Carrie L Key, Jason Card, Paul B Pashkov, Victor Patel, Anjana Bruick, Richard K Wurdak, Heiko Gardner, Kevin H
Published in
ACS chemical biology
For several well-documented reasons, it has been challenging to develop artificial small molecule inhibitors of protein/protein complexes. Such reagents are of particular interest for transcription factor complexes given links between their misregulation and disease. Here we report parallel approaches to identify regulators of a hypoxia signaling t...
Schulze, Christopher J Donia, Mohamed S Siqueira-Neto, Jair L Ray, Debalina Raskatov, Jevgenij A Green, Richard E McKerrow, James H Fischbach, Michael A Linington, Roger G
Published in
ACS chemical biology
Marine natural products are an important source of lead compounds against many pathogenic targets. Herein, we report the discovery of lobosamides A-C from a marine actinobacterium, Micromonospora sp., representing three new members of a small but growing family of bacterially produced polyene macrolactams. The lobosamides display growth inhibitory ...
