Murine T cells reactive to type II collagen. II. Functional characterization.

Published in The Journal of Immunology

DBA/1 mice immunized with native chick type II collagen (NcII) emulsified in complete Freund s adjuvant develop arthritis, whose underlying mechanisms are still undefined. As an initial step to studying the role of T cells in collagen-induced arthritis (CIA), we have established T cell lines specific to type II collagen. Characterizations of the an...

T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage....

Published in Arthritis & Rheumatism

HAL: a hierarchical format for storing and analyzing multiple genome alignments.

Published in Bioinformatics

Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative spl...

Published in Proceedings of the National Academy of Sciences

The Ser/Arg-rich (SR) proteins constitute a family of highly conserved nuclear phosphoproteins that are involved in many steps of mRNA metabolism. Previously, we demonstrated that shuttling SR proteins can associate with translating ribosomes and enhance translation of reporter mRNAs both in vivo and in vitro. Here, we show that endogenous, cytopla...

Comprehensive molecular characterization of clear cell renal cell carcinoma.

Published in Nature

Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, PBRM1). We surveyed more than 400 tumours using different genomic platforms and identified 19 significantly mutated genes. The PI(3)K/AKT pathway...