Published in Clinical laboratory science : journal of the American Society for Medical Technology
Nationally, clinical laboratory science programs are struggling for student applicants. Major challenges facing the laboratory profession include: 1) low salaries, 2) lack of public awareness, and 3) the myriad of career choices for new graduates. Increasing public awareness and actively recruiting students can overcome one of these challenges. Thi...
Published in Molecular Brain Research
Cryptochrome is a blue-light absorbing photopigment that has been proposed to act as a photoreceptor for a variety of nonvisual light-responsive tasks. While mouse models have suggested an important role for cryptochrome in nonvisual photoreception, there are no biochemical data demonstrating the functional photoreceptive capability of cryptochrome...
Published in The Journal of Cell Biology
NAP1 is a 60-kD protein that interacts specifically with mitotic cyclins in budding yeast and frogs. We have examined the ability of the yeast mitotic cyclin Clb2 to function in cells that lack NAP1. Our results demonstrate that Clb2 is unable to carry out its full range of functions without NAP1, even though Clb2/p34CDC28-associated kinase activit...
Published in Future Medicinal Chemistry
The discovery of various regulatory, protective and deleterious effects of nitric oxide (NO) has prompted intense research activity in the design and synthesis of NO-donating drugs and materials that can be used to modulate the effective concentrations of NO at biological targets. To date, various NO-donating compounds have been incorporated or imm...
Published in Chemistry & Biology
Cytological profiling is a high-content image-based screening technology that provides insight into the mode of action (MOA) for test compounds by directly measuring hundreds of phenotypic cellular features. We have extended this recently reported technology to the mechanistic characterization of unknown natural products libraries for the direct pr...
Published in Proceedings of the National Academy of Sciences
Evidence from numerous cancers suggests that increased aggressiveness is accompanied by up-regulation of signaling pathways and acquisition of properties common to stem cells. It is unclear if different subtypes of late-stage cancer vary in stemness properties and whether or not these subtypes are transcriptionally similar to normal tissue stem cel...
Published in American Journal of Obstetrics and Gynecology
Cycles of gonadotropin treatment were studied to gain information concerning the mechanisms involved in the postovulatory change in estriol (E3) production, particularly as regards the part played by progesterone, as it was previously postulated that progesterone was involved in this change. The subjects for the study were 4 young women who had reg...
Published in Physical Review Letters
Published in PLoS Computational Biology
Taking advantage of the complete genome sequences of several mammals, we developed a novel method to detect losses of well-established genes in the human genome through syntenic mapping of gene structures between the human, mouse, and dog genomes. Unlike most previous genomic methods for pseudogene identification, this analysis is able to different...
Published in Genome Research
The NCBI Reference Sequence (RefSeq) project and the NIH Mammalian Gene Collection (MGC) together define a set of approximately 30,000 nonredundant human mRNA sequences with identified coding regions representing 17,000 distinct loci. These high-quality mRNA sequences allow for the identification of transcribed regions in the human genome sequence,...
